Two Novel Bacteriophages Improve Survival in Galleria mellonella Infection and Mouse Acute Pneumonia Models Infected with Extensively Drug-Resistant Pseudomonas aeruginosa

• Jongsoo Jeon ^[1] ; Dongeun Yong ^[1]
  1. [1] Yonsei University

     Yonsei University

     Corea del Sur

     
• Localización: Applied and Environmental Microbiology, ISSN 0099-2240, Vol. 85, Nº 9, 2019
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • In this study, two novel P. aeruginosa phages, Bϕ-R656 and Bϕ-R1836, were evaluated in vitro, in silico, and in vivo for therapeutic efficacy and safety as an alternative antibacterial agent to control XDR-PA strains collected from pneumonia patients. Both phages exhibited potent bacteriolytic activity and greatly improved survival in G. mellonella larva infection and a mouse acute pneumonia model. Based on these results, we strongly predict that these two new phages could be used as fast-acting and safe alternative biological weapons against XDR-PA infections.