Deception through mimicry: a cellular antiviral strategy

• Nicholas C. Wu ^[1] ; Andrew B. Ward ^[1]
  1. [1] Scripps Research Institute

     Scripps Research Institute

     Estados Unidos

     
• Localización: Cell, ISSN 0092-8674, Vol. 175, Nº. 7, 2018, págs. 1728-1729
• Idioma: inglés
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• Resumen

  • Viruses use mimicry to hijack cellular machinery, but can human cells use mimicry as an antiviral approach? Batra et al. identify a novel antiviral restriction factor, RBBP6, by characterizing the cellular interactome of Ebola virus. RBBP6 targets the Ebola virus transcription factor VP30 by mimicking the binding of Ebola virus nucleoprotein.