N4-acetylation of Cytidine in mRNA by NAT10 Regulates Stability and Translation

• Dan Dominissini ^[1] ; Gideon Rechavi ^[1]
  1. [1] Tel Aviv University

     Tel Aviv University

     Israel

     
• Localización: Cell, ISSN 0092-8674, Vol. 175, Nº. 7, 2018, págs. 1725-1727
• Idioma: inglés
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• Resumen

  • Arango et al. expand the repertoire of epitranscriptomic modifications by identifying N4-acetylcytidine in mRNA catalyzed by the known dual acetyltransferase NAT10. It occurs mainly in the coding sequence, likely in wobble positions of select codons, where it promotes stability and translation, possibly by safeguarding cognate codon-anticodon interaction.