Phase Separation, Protein Disorder, and Enhancer Function

• Steven Hahn ^[1]
  1. [1] Fred Hutchinson Cancer Research Center
• Localización: Cell, ISSN 0092-8674, Vol. 175, Nº. 7, 2018, págs. 1723-1725
• Idioma: inglés
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• Resumen

  • New findings suggest that transcription enhancers work by recruitment of a large dynamic network of coactivators and other factors responsible for gene activation. Formation of these condensates is driven by DNA-bound transcription factors, their intrinsically disordered activation domains, and dynamic low-specificity interactions within the complex.