Effects of short term experimental diabetes on brain serotonin metabolism

• Autores: Gerardo Atienza Merino, Manuel Alejo Aldegunde Villar, Rafael Durán Barbosa
• Localización: Revista española de Fisiología, ISSN 0034-9402, Vol. 44, Nº. 3, 1988, págs. 279-282
• Idioma: inglés
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• Resumen

  • Serotonin metabolism was studied in several brain regions of control and Streptozotocin-treated male Wistar rats. After induction of diabetes, the animals were killed at 24 hours. Concentrations of brain tryptophan show a generalized increase in all brain regions, being only significant in medulla-pons. Serotonin levels do not change, while 5-HIAA concentrations, as well as the ratio 5-HIAA/5-HT, show significant increases in medulla-pons and mid-brain.