Neuromodulatory Activity of Dietary Phenolics Derived from Corchorus olitorius L.

• Wagdy, Reham ^[2] ; Abdelkader, Reham M ^[3] ; El-Khatib, Ahmed H ^[4] ; Linscheid, Michael W ^[1] ; Hamdi, Nabila ^[3] ; Handoussa, Heba ^[2]
  1. [1] Humboldt University of Berlin

     Humboldt University of Berlin

     Berlin, Stadt, Alemania

     
  2. [2] Faculty of Pharmacy and Biotechnology, Dept. of Pharmaceutical Biology, German Univ. in Cairo
  3. [3] Faculty of Pharmacy and Biotechnology, Dept. of Pharmacology and Toxicology, German Univ. in Cairo
  4. [4] Faculty of Pharmacy and Biotechnology, Dept. of Pharmaceutical Analytical Chemistry, Ain Shams Univ., Cairo

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• Localización: Journal of food science, ISSN 0022-1147, Vol. 84, Nº 5, 2019, págs. 1012-1022
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Dietary phenolics are known for their potent antioxidant and anti-inflammatory activities, making them promising candidates for protection against neuroinflammation and neurodegeneration. Hydroalcohol extract of Egyptian species of Corchorus olitorius L. (Co) leaves was investigated for its neuroprotective effects in a lipopolysaccharide-induced neuroinflammatory mouse model. Twenty five metabolites were characterized from the bioactive extract using high-performance liquid chromatography HPLC/PDA/HRESI/MSn , revealing 1,5-dicaffeoylquinic acid (Co11) as one of the major constituents (5.7%), which was isolated and its identity was confirmed by spectral data as first report. Co significantly protected microglia against H2 O2 -induced cytotoxicity and immunohistochemistry showed reduced expression of the astrocytic marker, glial fibrillary acidic protein, and the inflammatory marker, cyclooxygenase-2. These findings correlated with significant improvement of cognitive functions and reduction of LPS-induced neurodegeneration in Co-treated mice as revealed by histopathology. The current study shows promising effects of Co in limiting neurodegeneration and cognitive impairment caused by neuroinflammation and glial cell activation. PRACTICAL APPLICATION: Information presented here shed light on the promising effects of Corchorus olitorius (Co) for the modulation of neuroinflammatory pathways improving the neuroinflammation-related neurodegeneration and cognitive decline. This makes Co a promising candidate as a nutraceutical supplement to be used against neuroinflammation-related disorders.; © 2019 Institute of Food Technologists®.