Cell-free DNA and preoperative chemoradiotherapy for rectal cancer:: a systematic review

• Anders Kindberg Boysen ^[1] ; Karen-Lise Garm Spindler ^[1] ; Jakob Vasehus Schou ^[2]
  1. [1] Aarhus University

     Aarhus University

     Dinamarca

     
  2. [2] Copenhagen University HospitalHellerupDenmark
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 21, Nº. 7, 2019, págs. 874-880
• Idioma: inglés
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• Resumen

  • Background Preoperative chemoradiotherapy is the standard of care for patients with locally advanced rectal cancer, yet valid circulating biomarkers are lacking. We aimed at systematically reviewing the literature of cell-free DNA and locally advanced rectal cancer.

    Methods A systematic literature search was performed. We retrieved papers reporting a correlation between a clinical outcome and cell-free DNA for patients receiving chemoradiotherapy for locally advanced rectal cancer.

    Results We included nine studies of a total of 615 patients. Only single-arm studies were identified, analyzing either the total level of cell-free DNA or tumor-specific DNA. Despite differences in the methodology and outcomes, eight of the nine studies showed a correlation between cell-free DNA and a clinical outcome.

    Conclusions Cell-free DNA might hold prognostic and predictive information for patients with locally advanced rectal cancer receiving preoperative chemoradiotherapy; although, firm conclusions are limited by the heterogeneity in this field.