‘NOTCHing up’ the in vitro production of dendritic cells

• Autores: Martin Guilliams, Charlotte L. Scott
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 39, Nº. 10, 2018, págs. 765-767
• Idioma: inglés
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• Resumen

  • Two studies show that adding NOTCH ligands to Flt3L cultures increases the yield of cDC1s from mouse and human progenitors. Moreover, these NOTCH-DCs more closely resemble in vivo DCs transcriptionally and functionally. This will be extremely valuable for studying DCs in vitro and for further developing autologous DC-based antitumor vaccinations