Divergent Roles of Antiself Antibodies during Infection
- Autores: Juan Rivera Correa, Ana Rodriguez
- Localización: Trends in immunology, ISSN 1471-4906, Vol. 39, Nº. 7, 2018, págs. 515-522
- Idioma: inglés
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Resumen
Antiself antibodies are most commonly associated with autoimmune disorders, but a large body of evidence indicates that they are also present in numerous infectious diseases. These autoimmune antibodies appear transiently during infection with a number of viruses, bacteria, and parasites and in some cases have been associated with the development of autoimmune disorders that develop after infection has been cleared. Traditionally these infection-associated autoantibodies are considered an erroneous byproduct of a legitimate immune response, but their possible role in the clearance of microbes and infected cells or inhibition of host-cell invasion suggests that they may be present because of their beneficial protective role against various infections.
