The helix twist: damage and repair follows the dna minor groove

• Eran Kotler ^[1] ; Eran Segal ^[1]
  1. [1] Weizmann Institute of Science

     Weizmann Institute of Science

     Israel

     
• Localización: Cell, ISSN 0092-8674, Vol. 175, Nº. 4, 2018, págs. 902-904
• Idioma: inglés
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• Resumen

  • Mutation frequencies vary along the genome, but the factors determining this variability are only partially understood. Pich et al. unravel a ∼10 bp periodicity in mutation rates at nucleosome-proximal regions that follows minor groove orientation. Opposing differential DNA damage and repair processes could shape genetic divergence irrespective of selection.