Six years after the FTO gene was linked with obesity, people finally have a handle on how it works. It stops them feeling full after meals, and makes calorific food more alluring. Rachel Batterham of University College London and her colleagues say people with the gene variant don't suppress ghrelin properly after a meal, so they remain hungry. Andrew Hattersley of the University of Exeter in UK says the work is exciting but that "further studies are needed to make sure the effect is entirely through ghrelin.
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