Resumen de The impact of humus water on inflammatory cytokines of endothelial cells cultured under conditions of hyperglycemia

K. Szot, K. Góralczyk, M. Michalska, N. Veryho, J. Chojnowski, I. Ponikowska, D. Rość

• Introduction: Diabetes has become an epidemic and is a risk factor of cardiovascular disease. Hyperglycemia in diabetes is responsible for damaging of the endothelium and increases inflammation on the surface of the vascular lining. The inflammatory process in diabetes is associated with the secretion of inflammatory cytokines by endothelial cells, e.g., tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) and by a reduction of cell proliferation.

  Humus waters (HW) containing humus acids with sources in Poland are originally bacteriologically pure, physically and chemically stable. Because of the physicochemical properties of humus acids of adsorption, complexation and ion exchange they present numerous therapeutic activities including anti-inflammatory.

  Data regarding its molecular mechanisms underlying these phenomena are scarce.

  The present study reveals that humus water exerts important beneficial effects on endothelial cells under conditions of hyperglycemia.