Resumen de ACE Gene Plays a Key Role in Reducing Blood Pressure in The Hyperintensive Elderly After Resistance Training
Fabio T. Montrezol, Rodolfo Marinho, Gloria de F.A. da Mota, Vânia D' Almeida, Edilamar M. de Oliveira, Ricardo José Gomes, Alessandra Medeiros
Hypertension is a difficult disease to control and exercise training plays a key role in hypertension control. Some individuals are not responsive to exercise training; so, we highlight the polymorphism of I allele of angiotensin-converting enzyme (ACE) as a factor responsible for this lack of responsiveness. The aim of this study was to evaluate the influence of ACE insertion/deletion genotypes on effects of resistance training on blood pressure (BP) and chronic inflammation. Eighty-six hypertensive volunteers, aged between 60 and 80, were evaluated. They performed 16 weeks of resistance training at 50% of 1 maximal repetition. The greatest benefits were seen on homozygous of the Insertion allele, whom presented reduction of systolic blood pressure (SBP: 129.31 +/- 13.34 vs. 122.56 +/- 9.68 mm Hg, p < 0.001) and diastolic blood pressure (DBP: 79.18 +/- 8.05 vs. 70.12 +/- 7.71 mm Hg, p < 0.01) during daytime period, and in 24-hour period (SBP: 127.12 +/- 13.65 vs. 121.06+/- 9.68 mm Hg, p < 0.001 and DBP: 71.87 +/- 8.39 vs. 68.75 +/- 8.72 mm Hg, p < 0.05) and also increased circulating adiponectin levels (4.04 +/- 1.79 vs. 6.00 +/- 2.81 ng[middle dot]ml-1, p < 0.01). Other genotypes showed no changes in BP and biochemical parameters. Our results suggest a cardio protective factor of I allele because only those homozygous showed reductions in BP and increases in adiponectin.
