As people age, mitochondrial function declines, which can lead to disease. To investigate why, Ana Gomes at Harvard Medical School and her colleagues compared levels of messenger RNA--molecules that convey genetic information around a cell--for the cellular components needed for respiration in the skeletal muscle of 6 and 22-month-old mice. Levels of mRNA in the nucleus were similar in young and old mice, while levels in the mitochondria decreased with age. This suggests that communication between the nucleus and the mitochondria depends on events involving both these proteins.
© 2001-2024 Fundación Dialnet · Todos los derechos reservados