Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1

• Haiyang Yu ^[1] ; Don W. Cleveland ^[1]
  1. [1] University of California at San Diego
• Localización: Cell, ISSN 0092-8674, Vol. 174, Nº. 6, 2018, págs. 1339-1341
• Idioma: inglés
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• Resumen

  • Partial loss of TANK-binding kinase 1 (TBK1) causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Xu et al. identify the role of TBK1 in suppressing neuroinflammation and apoptosis by its inhibition of the receptor-interacting serine/threonine-protein kinase 1 (RIPK1 ) and elucidate how aging and genetic susceptibility together cause neuroinflammation.