Association of cigarette smoking with HIV prognosis among women in the HAART era: a report from the women's interagency HIV study.

• Autores: Joseph G Feldman, Howard Minkoff, Michael F Schneider, Stephen J. Gange, Mardge Cohen, D. Heather Watts, Monica Gandhi, Robert S Mocharnuk, Kathryn Anastos
• Localización: American journal of public health, ISSN 0090-0036, Vol. 96, Nº. 6, 2006, págs. 1060-1065
• Idioma: inglés
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• Resumen

  • Objective: We assessed the association of cigarette smoking with the effectiveness of highly active antiretroviral therapy (HAART) among low-income women.; Methods: Data were analyzed from the Women's Interagency HIV Study, a multisite longitudinal study up to 7.9 years for 924 women representing 72% of all women who initiated HAART between July 1, 1995, and September 30, 2003.; Results: When Cox's regression was used after control for age, race, hepatitis C infection, illicit drug use, previous antiretroviral therapy, and previous AIDS, smokers on HAART had poorer viral responses (hazard ratio [HR]=0.79; 95% confidence interval [CI]=0.67, 0.93) and poorer immunologic response (HR=0.85; 95% CI=0.73, 0.99). A greater risk of virologic rebound (HR=1.39; 95% CI=1.06, 1.69) and more frequent immunologic failure (HR=1.52; 95% CI=1.18, 1.96) were also observed among smokers. There was a higher risk of death (HR=1.53; 95% CI=1.08, 2.19) and a higher risk of developing AIDS (HR=1.36; 95% CI=1.07, 1.72) but no significant difference between smokers and nonsmokers in the risk of death due to AIDS.; Conclusions: Some of the benefits provided by HAART are negated in cigarette smokers.;