Biomarkers of Tobacco Smoke Exposure in Racial/Ethnic Groups at High Risk for Lung Cancer.

• Autores: Pebbles Fagan, Eric T. Moolchan, Pallav Pokhrel, Thaddeus Herzog, Kevin D Cassel, Ian Pagano, Adrian A. Franke, Joseph Keawe’aimoku Kaholokula, Angela Sy, Linda A. Alexander, Dennis R Trinidad, Kari-Lyn Sakuma, C. Anderson Johnson, Alyssa Antonio, Dorothy Jorgensen, Tania Lynch, Crissy Kawamoto, Mark S. Clanton
• Localización: American journal of public health, ISSN 0090-0036, Vol. 105, Nº. 6, 2015, págs. 1237-1245
• Idioma: inglés
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• Resumen

  • Objectives. We examined biomarkers of tobacco smoke exposure among Native Hawaiians, Filipinos, and Whites, groups that have different lung cancer risk. Methods. We collected survey data and height, weight, saliva, and carbon monoxide (CO) levels from a sample o f daily smokers aged 18-35 (n = 179). Mean measures o f nicotine, cotinine, cotinine/cigarettes per day ratio, trans 3' hydroxycotinine, the nicotine metabolite ratio (NMR), and expired CO were compared among racial/ethnic groups. Results. The geometric means fo r cotinine, the cotinine/cigarettes per day ratio, and CO did not significantly differ among racial/ethnic groups in the adjusted models. After adjusting fo r gender, body mass index, menthol smoking, Hispanic ethnicity, and number o f cigarettes smoked per day, the NMR was significantly higher among Whites than among Native Hawaiians and Filipinos (NMR = 0.33, 0.20, 0.19, P<.001). The NMR increased with increasing White parental ancestry. The NMR was not significantly correlated with social-environmental stressors. Conclusions. Racial/ethnic groups with higher rates of lung cancer had slower nicotine metabolism than Whites. The complex relationship between lung cancer risk and nicotine metabolism among racial/ethnic groups needs further clarification. [ABSTRACT FROM AUTHOR]