Inter-observer variation of hippocampus delineation in hippocampal avoidance prophylactic cranial irradiation

• F. Bartel ^[1] ; M. van Herk ^[2] ; H. Vrenken ^[1] ; F. Vandaele ^[7] ; S. Sunaert ^[3] ; K. de Jaeger ^[8] ; N. J. Dollekamp ^[4] ; C. Carbaat ^[9] ; E. Lamers ^[9] ; E. M. T. Dieleman ^[5] ; Y. Lievens ^[6] ; D. de Ruysscher ^[10] ; S. B. Schagen ^[9] ; M. B. de Ruiter ^[9] ; J. C. de Munck ^[1] ; Jose Belderbos ^[9]
  1. [1] VU University Medical Center

     VU University Medical Center

     Países Bajos

     
  2. [2] University of Manchester

     University of Manchester

     Reino Unido

     
  3. [3] Europe Hospitals

     Europe Hospitals

     Arrondissement Brussel-Hoofdstad, Bélgica

     
  4. [4] University Medical Center

     University Medical Center

     Estados Unidos

     
  5. [5] Academic Medical Center

     Academic Medical Center

     Países Bajos

     
  6. [6] Ghent University

     Ghent University

     Arrondissement Gent, Bélgica

     
  7. [7] Iridium Cancer Network, Bélgica
  8. [8] Catharina Hospital, Países Bajos
  9. [9] Netherlands Cancer Institute, Países Bajos
  10. [10] Maastricht University Medical Center, Países Bajos

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• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 21, Nº. 2 (February), 2019, págs. 178-186
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Background Hippocampal avoidance prophylactic cranial irradiation (HA-PCI) techniques have been developed to reduce radiation damage to the hippocampus. An inter-observer hippocampus delineation analysis was performed and the influence of the delineation variability on dose to the hippocampus was studied.

    Materials and methods For five patients, seven observers delineated both hippocampi on brain MRI. The intra-class correlation (ICC) with absolute agreement and the generalized conformity index (CIgen) were computed. Median surfaces over all observers’ delineations were created for each patient and regional outlining differences were analysed. HA-PCI dose plans were made from the median surfaces and we investigated whether dose constraints in the hippocampus could be met for all delineations.

    Results The ICC for the left and right hippocampus was 0.56 and 0.69, respectively, while the CIgen ranged from 0.55 to 0.70. The posterior and anterior-medial hippocampal regions had most variation with SDs ranging from approximately 1 to 2.5 mm. The mean dose (Dmean) constraint was met for all delineations, but for the dose received by 1% of the hippocampal volume (D1%) violations were observed.

    Conclusion The relatively low ICC and CIgen indicate that delineation variability among observers for both left and right hippocampus was large. The posterior and anterior-medial border have the largest delineation inaccuracy. The hippocampus Dmean constraint was not violated.