The inner life of the genome.

• Autores: Tom Misteli
• Localización: Scientific American, ISSN 0036-8733, Vol. 304, Nº. 2, 2011, págs. 66-73
• Idioma: inglés
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• Resumen

  • The article discusses the influence on cell function in health and disease as a result of the way human genes are arrayed and their movement in the three-dimensional (3-D) space of a cell's nucleus. According to the author, chromosomes occupy preferred positions within the cell nucleus rather than existing there randomly. He notes that the nuclear organization of chromosomes is reflective of their functional state, including the gene it carries, and that the organization can change in response to changes in the cell's behavior or disease. Topics include an overview of how the identification of the locations that genes occupy within the nucleus and understanding how these positions change under different conditions is offering clues to how normal cells function and how diseases arise. INSETS: Organized at Many Levels;A Hallmark of Cancer Is Explained.