Developmental Origin Governs CD8+ T Cell Fate Decisions during Infection

• Norah L. Smith ^[1] ; Ravi K. Patel ^[1] ; Arnold Reynaldi ^[2]
  1. [1] Cornell University

     Cornell University

     City of Ithaca, Estados Unidos

     
  2. [2] Kirby Institute for Infection and Immunity, UNSW
• Localización: Cell, ISSN 0092-8674, Vol. 174, Nº. 1, 2018, págs. 117-130
• Idioma: inglés
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• Resumen

  • Heterogeneity is a hallmark feature of the adaptive immune system in vertebrates. Following infection, naive T cells differentiate into various subsets of effector and memory T cells, which help to eliminate pathogens and maintain long-term immunity. The current model suggests there is a single lineage of naive T cells that give rise to different populations of effector and memory T cells depending on the type and amounts of stimulation they encounter during infection. Here, we have discovered that multiple sub-populations of cells exist in the naive CD8 + T cell pool that are distinguished by their developmental origin, unique transcriptional profiles, distinct chromatin landscapes, and different kinetics and phenotypes after microbial challenge. These data demonstrate that the naive CD8 + T cell pool is not as homogeneous as previously thought and offers a new framework for explaining the remarkable heterogeneity in the effector and memory T cell subsets that arise after infection.