Disparate Inclusion of Older Adults in Clinical Trials: Priorities and Opportunities for Policy and Practice Change.

• Autores: Angelica P. Herrera, Shedra Amy Snipes, Denae W. King, Isabel Torres-Vigil, Daniel S. Goldberg, Armin D. Weinberg
• Localización: American journal of public health, ISSN 0090-0036, Vol. 100, Nº. 0, 2010, págs. 105-112
• Idioma: inglés
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• Resumen

  • Older adults are vastly underrepresented in clinical trials in spite of shouldering a disproportionate burden of disease and consumption of prescription drugs and therapies, restricting treatments' generalizability, efficacy, and safety. Eliminating Disparities in Clinical Trials, a national initiative comprising a stakeholder network of researchers, community advocates, policymakers, and federal representatives, undertook a critical analysis of older adults' structural barriers to clinical trial participation. We present practice and policy change recommendations emerging from this process and their rationale, which spanned multiple themes: (1) decision making with cognitively impaired patients; (2) pharmacokinetic differences and physiological age; (3) health literacy, communication, and aging; (4) geriatric training; (5) federal monitoring and accountability; (6) clinical trial costs; and (7) cumulative effects of aging and ethnicity. [ABSTRACT FROM AUTHOR]