Synthesis and Evaluation of Artificial DNA Scissors: An Interdisciplinary Undergraduate Experiment

• Autores: Jan Hormann, Sabine Streller, Nora Kulak
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 95, Nº 10, 2018, págs. 1848-1855
• Idioma: inglés
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• Resumen

  • Bridging organic and inorganic chemistry as well as molecular biology, this undergraduate experiment deals with the synthesis of ligands for metal complexes that can cleave DNA. Students gain theoretical and experimental expertise about metal–DNA interactions and the mechanisms behind DNA cleavage. This experiment lays a basis for the understanding and the rational design of artificial DNA scissors and provides insight into interdisciplinary research in the field of bioinorganic chemistry.