Organocatalytic Cyclopropanation of (E)-Dec-2-enal: Synthesis, Spectral Analysis and Mechanistic Understanding

• Autores: Marta Meazza, Agnieszka Kowalczuk, Sarah Watkins, Simon D. Holland, Thomas A. Logothetis, Ramon Rios
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 95, Nº 10, 2018, págs. 1832-1839
• Idioma: inglés
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• Resumen

  • An undergraduate experiment combining synthesis, NMR analysis and mechanistic understanding is reported. The students perform an organocatalyzed cyclopropanation reaction of (E)-dec-2-enal and are then required to determine the diastereoselectivity and assign the relative configuration of each product using NMR spectroscopy.