Features and roles of T helper 9 cells and interleukin 9 in immunological diseases

• R. Yazdani ^[2] ; N. Rezaei ^[2] ; S. Shapoori ^[1] ; M. Rezaeepoor ^[1] ; R. Sanaei ^[3] ; M. Ganjalikhani-Hakemi ^[1] ; G. Azizi ^[4] ; W. Rae ; A. Aghamohammadi
  1. [1] Isfahan University of Medical Sciences

     Isfahan University of Medical Sciences

     Irán

     
  2. [2] ehran University of Medical Science, Tehran, Iran
  3. [3] Iran University of Medical Science, Tehran, Iran
  4. [4] Alborz University of Medical Sciences, Karaj, Iran

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• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 47, Nº. 1, 2019, págs. 90-104
• Idioma: inglés
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• Resumen

  • T helper 9 (TH9) cells are considered as newly classified helper T cells that have an important role in the regulation of immune responses. Since these cells preferentially produce IL-9, these cells are termed TH9 cells. Recently, the role of TH9 and its signature cytokine (IL-9) has been investigated in a wide range of diseases, including autoimmunity, allergy, infections, cancer and immunodeficiency. Herein, we review the most recent data concerning TH9 cells and IL-9 as well as their roles in disease. These insights suggest that TH9 cells are a future target for therapeutic intervention.