Association between environmental exposure and CD4+CD25+ regulatory T cells

• P. Fuss ^[2] ; I. Stelmac ^[1] ; K. Bal ^[2] ; J. Jerzyńska ^[2] ; D. Podlecka ^[2] ; W. Stelmac ^[2]
  1. [1] Medical University of Lodz

     Medical University of Lodz

     Łódź, Polonia

     
  2. [2] opernicus Hospital, al. Pilsudskiego 71, 90-329, Lodz, Poland
• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 47, Nº. 1, 2019, págs. 43-46
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Background It is considered that farm areas protect young patients from allergy and asthma due to high exposure to endotoxins.

    Aim To compare CD4+/CD25+ T-regulatory cells and forkhead transcription factor Foxp3 expression in asthmatic children allergic to house dust mites (HDM) living in rural and farm areas.

    Materials and Methods This was a prospective analysis of 35 children living in farm areas (n=19) and rural areas (n=16), aged 8–16, with allergic rhinitis (allergic to dust mites) and newly diagnosed asthma. Surface molecule CD4+CD25+Foxp3+ expression on cultured PBMCs was estimated by flow cytometry using fluorophore-conjugated monoclonal antibodies in each patient.

    Results Thirty-five children were included into the analysis: 19 children living in farm areas and 16 in rural areas. Within and between-groups (farm area vs. rural area) differences in CD4+/CD25+ and CD4+/CD25+Foxp3+ cell expression did not reach the level of significance.

    Conclusion The current analysis showed that CD4+/CD25+ and CD4+/CD25+Foxp3+ cell expression was not associated with place of living in asthmatic children sensitive to HDM.