Prevalence of self-reported drug hypersensitivity reactions among Lithuanian children and adults

V. Kvedariene; P. Demol; B. Sitkauskiene; L. Tamasauskiene; O. Rudzeviciene; V. Kasiulevicius

Ayuda

Prevalence of self-reported drug hypersensitivity reactions among Lithuanian children and adults

V. Kvedariene ^[4] ; P. Demol ^[1] ; B. Sitkauskiene ^[2] ; L. Tamasauskiene ^[2] ; O. Rudzeviciene ^[3] ; V. Kasiulevicius ^[3]
1. [1] Sorbonne Universités
  
  Sorbonne Universités
  
  París, Francia
2. [2] Lithuanian University of Health Sciences
  
  Lithuanian University of Health Sciences
  
  Lituania
3. [3] Vilnius University
  
  Vilnius University
  
  Lituania
4. [4] Institute of Clinical Medicine, M.K. Ciurlionio Street 21, LT-03101 Vilnius, Lithuania
Mostrar afiliaciones +
Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 47, Nº. 1, 2019, págs. 32-37
Idioma: inglés
Texto completo no disponible (Saber más ...)
Resumen
- Introduction and objectives Drug hypersensitivity reactions (DHRs) are the adverse effects of drugs that, when taken at doses generally tolerated by normal subjects, clinically resemble allergy. We aimed to assess the prevalence of self-reported DHRs among Lithuanian children and adults and to identify possible risk factors.
  
  Materials and methods A cross-sectional survey of a population visiting their general practitioners in Vilnius and Kaunas regions of Lithuania was performed. Thirty-five questions on drug allergy symptoms, in addition, food, pollen allergy and family history were included.
  
  Results 3222 (60.0%) children and 2148 (40.0%) adults were included in the study. 7.9% of children and 13.8% of adults reported a DHR for at least one drug (p<0.001). 69.8% of children and 47.3% of adults, who indicated DHRs, had skin symptoms. Rate of anaphylaxis was similar in both groups (about 10%). 4.5% of children and 7.3% of adults had DHRs induced by antibiotics and this was the most implicated group of drugs. Significant self-reported risk factors for DHRs were family history of DHRs (OR=6.007, 95%CI 4.756–7.587), pollen allergy (OR=2.0, 95%CI 1.573–2.544), food allergy (OR=1.92, 95%CI 1.505–2.448), female gender (OR=1.439, 95%CI 1.187–1.744) and age (OR=1.017 in favour of adults, 95%CI 1.013–1.021).
  
  Conclusions The prevalence of self-reported DHRs in Lithuania is higher among adults than children. Drug-induced skin reactions were the predominant symptom in both groups. Besides female gender and age, a positive family history of DHR and presence of pollen or food allergy may be associated with DHR.