Direct visualization of wide fusion-fission pores and their highly varied dynamics

• Autores: Katherine W. Eyring, Richard W. Tsien
• Localización: Cell, ISSN 0092-8674, Vol. 173, Nº. 4, 2018, págs. 819-821
• Idioma: inglés
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• Resumen

  • In this issue of Cell, Shin et al. report the first live-cell imaging of a fusion pore. Directly visualized pores in neuroendocrine cells can be much larger than expected yet not require vesicular full-collapse. These fusion-fission pores have diverse fates arising from opposing dynamin-driven pore constriction and F-actin-mediated pore expansion.