Chemistry takes center stage for identifying cancer targetability

• Autores: Christopher Parker, Benjamin F. Cravatt
• Localización: Cell, ISSN 0092-8674, Vol. 173, Nº. 4, 2018, págs. 815-817
• Idioma: inglés
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• Resumen

  • Matching genetically defined cancer states to drugs that specifically target these states is a principal goal of personalized oncology medicine. In this issue, McMillan et al. show how large-scale chemical screening coupled to deep molecular profiling can identify mechanistically diverse druggable vulnerabilities for genetic subtypes of lung cancers.