Preemptive analgesia-related gene and protein expression in third molar surgeries under non steroidal anti-inflammatory drug protocols: A PROSPERO-registered systematic review of clinical studies

• Assis-Filipe Medeiros-Albuquerque ^[1] ; Carline-Maria Sampaio-Melo ^[2] ; Eduardo-Costa Studart-Soares ^[1] ; Thyciana Rodrigues-Ribeiro ^[1] ; Cristiane-Sá Roriz-Fonteles ^[1] ; Karuza-Maria Alves-Pereira ^[1] ; Daniel-Almeida Ferreira-Barbosa ^[1] ; Paulo-Goberlânio de-Barros-Silva ^[1] ; Fábio-Wildson Gurgel-Costa ^[1]
  1. [1] Universidade Federal do Ceará

     Universidade Federal do Ceará

     Brasil

     
  2. [2] Student in Dentistry, School of Dentistry, Fortaleza University (UNIFOR), Ceará, Fortaleza, Brazil
• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 23, Nº. 6 (November ), 2018
• Idioma: inglés
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• Resumen

  • This study aimed to review translational studies focusing on third molar removal surgeries through a systematic analytical approach.

    A PROSPERO-registered systematic review (CRD42017060455) was conducted following the PRISMA statement to summarize current knowledge on gene expression in third molar surgeries. A search was performed in PubMed’s Medline and Scopus databases, without date or language restrictions, using the logical expression {[(Third molar) OR (preemptive) OR (cyclooxygenase inhibitors) OR (acute inflammation) AND (gene expression)]}.

    All studies included in the analysis evaluated gene expression in a third molar extraction model, using the preemptive analgesia methodology in seven investigations. The sample analyzed was obtained from gingival tissue biopsy (n=4), blood (n=1), transudate (n=1) and gingival tissue biopsy/transudate (n=1). There were differences with respect to evaluated genes, drug protocol, sample studied, and method for evaluating gene expression.

    Third molar surgeries were found to be associated with different COX-related gene expression patterns. Although inflammatory events following the surgical procedure are associated with COX isoforms, data from preemptive analgesia studies are scarce, especially from studies correlating gene expression and clinical parameters. In the future, from a clinical perspective, identifying the molecular targets of a drug based on individual gene expression may be helpful to delineate specific third molar, surgery-related, preemptive analgesia protocols.