Beyond the transport function of import receptors: what’s all the fus about?

• Autores: Sofya Mikhaleva, Edward A. Lemke
• Localización: Cell, ISSN 0092-8674, Vol. 173, Nº. 3, 2018, págs. 549-553
• Idioma: inglés
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• Resumen

  • Nuclear import receptors are central players in transporting protein cargoes into the nucleus. Moving beyond this role, four newly published articles describe a function in regulating supramolecular assemblies by fine-tuning the phase separating properties of RNA-binding proteins, which has implications for a variety of devastating neurodegenerative disorders.