A mechanosensitive GPCR that detects the bloody force

• Autores: Adam J. Iliff, X.Z. Shawn Xu
• Localización: Cell, ISSN 0092-8674, Vol. 173, Nº. 3, 2018, págs. 542-544
• Idioma: inglés
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• Resumen

  • Mechanoreceptors mediate a wide variety of physiological processes, such as hearing, touch, proprioception, and blood flow regulation. It is generally believed that mechanoreceptors are force-gated ion channels. Now, Xu et al. uncover a GPCR that is activated by shear force in endothelial cells of blood vessels.