Resumen de Renal injury in female dogs with pyometra

Mariana da Silva de Figueiredo, Christina Malm, Leonardo Dias Mamão, Juliana de Oliveira, Júlio César Cambraia Veado, Mariana de Pádua Costa, Pâmela Cristina Lopes Gurgel Valente, Rodrigo dos Santos Horta, Marina Lopes Castro, Aline Gomes de Castro, Leila Sbaraini, Eliana Matias de Souza

• English

  Pyometra is a common disease in intact female dogs and can cause glomerulopathy and tubular injury. This study aimed to evaluate kidney injury in female dogs with pyometra, as well as progression of the injury during treatment and the markers of this condition. This study analyzed 20 intact female dogs with both clinical and sonographic diagnosis of pyometra. Dogs were treated with intravenous fluids and antibiotics, and an ovariohysterectomy was performed. The following parameters were assessed at eight separate time points: blood pressure; serum creatinine, phosphorus, and urea levels; urinalysis and urinary biochemical parameters [urinary gamma-glutamyl transferase (uGGT) and urinary protein-to-creatinine ratio (UPCR)]; glomerular filtration rate (GFR); and urine output. All dogs showed some degree of kidney injury at the time of pyometra diagnosis. This was transient in most animals, resolving with treatment of the pyometra. Measurement of uGGT and UPCR identified renal parenchymal injury, helping to determine the prognosis of the animals analyzed in the present study.

  Key words: kidney disease; kidney function; urinary GGT; urinary protein-to-creatinine ratio; glomerular filtration rate

• português

  A piometra é afecção frequente em cadelas e pode causar glomerulopatias e lesões tubulares. O presente estudo objetivou avaliar injúria renal em cadelas com piometra, sua progressão ao longo do tratamento e o uso de marcadores dessa alteração. Participaram 20 cadelas com diagnóstico clínico e ultrassonográfico de piometra, submetidas à fluidoterapia, antibioticoterapia e ovariohisterectomia. Foram avaliados pressão arterial, concentração sérica de creatinina, fósforo e ureia; urinálise e bioquímica urinária (gama-glutamiltransferase urinária e razão proteína/creatinina urinárias), taxa de filtração glomerular e débito urinário, em oito tempos. Todas as cadelas apresentaram algum grau de injúria renal no momento do diagnóstico da piometra, sendo transitória na maioria dos animais após o tratamento. O uso de marcadores de injúria renal identificou lesão de parênquima renal, contribuindo com o prognóstico dos animais estudados.

  Palavras-chave: cadela; doença renal; função renal; piometra