Hiperfosfatasemia no familiar asintomática persistente: nota clínica

• Autores: Joan Dalmau Carolà
• Localización: Revista Española de Enfermedades Metabólicas Oseas, ISSN-e 1132-8460, Vol. 15, Nº. 1, 2006, págs. 18-20
• Idioma: español
• Títulos paralelos:
  • Persistent non-familial asymptomatic hyperphosphatasemia: Clinical note.
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• Resumen
  • español

    Hay múltiples causas de hiperfosfatasemia. La hiperfosfatasemia no familiar asintomática persistente es una entidad excepcionalmente referenciada en la literatura médica. Tiene que diferenciarse de otras entidades, como la hiperfosfatasemia esporádica y la hiperfosfatasemia familiar asintomática, entre otras. Se describe el caso de una hiperfosfatasemia no familiar asintomática persistente, seguida durante 18 años, en la que se pudo documentar una osteoporosis de turnover alto en hueso compacto, con una biopsia ósea transilíaca de hueso sin descalcificar, con marcaje con tetraciclinas. El reconocimiento de esta anomalía puede evitar retardo diagnóstico, inquietudes en el paciente y exploraciones innecesarias. There are several causes of hyperphosphatasemia. Persistent non-familial asymptomatic hyperphosphatasemia, for its part, rarely appears in the medical literature. There should be made a distinction between it and such entities as transient hyperphosphatasemia and familial asymptomatic hyperphosphatasemia, among others. Herein is presented a case of persistent non-familial asymptomatic hyperphosphatasemia followed up over an 18 year period. In it was demonstrated a high turnover osteoporosis in compact bone through the use of iliac bone crest biopsy and tetracycline marking. Failure to recognize this condition can cause diagnostic delay and patient anxiety, as well as lead to requests for unnecessary medical tests.

  • English

    There are several causes of hyperphosphatasemia. Persistent non-familial asymptomatic hyperphosphatasemia, for its part, rarely appears in the medical literature. There should be made a distinction between it and such entities as transient hyperphosphatasemia and familial asymptomatic hyperphosphatasemia, among others. Herein is presented a case of persistent non-familial asymptomatic hyperphosphatasemia followed up over an 18 year period. In it was demonstrated a high turnover osteoporosis in compact bone through the use of iliac bone crest biopsy and tetracycline marking. Failure to recognize this condition can cause diagnostic delay and patient anxiety, as well as lead to requests for unnecessary medical tests.