Hypoglycemic Activity of Polysaccharides from Sweet Corncob on Streptozotocin‐Induced Diabetic Rats

• Autores: Yong Qiang Ma, Xin Wang, Shuang Gao
• Localización: Journal of food science, ISSN 0022-1147, Vol. 82, Nº 1, 2017, págs. 208-213
• Idioma: inglés
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• Resumen

  • A water‐soluble polysaccharide (SCP‐80‐I) was isolated from sweet corncob using microwave‐assisted compound‐enzyme extraction and column chromatography. SCP‐80‐I is composed mainly of arabinose, mannose, glucose, and galactose in a molar ratio of 0.369:0.824:10.759:0.333, and has a molecular mass of 18350 Da and β‐glycosides linkages in its molecular structure. The preliminary hypoglycemic and hypolipidemic activity in streptozotocin‐induced diabetic rats was investigated. Rats were administered daily with 100, 200, and 400 mg/kg SCP‐80‐I for 21 d. The SCP‐80‐I increased the rat body mass significantly and reduced the blood glucose level in a dose‐dependent manner. The SCP‐80‐I reduced liver swelling; kidney and pancreas hypertrophy; and total cholesterol, triglyceride, and low‐density lipoprotein‐C levels significantly; and increased the level of high‐density lipoproteins in streptozotocin‐induced diabetic rats. These results indicate that SCP‐80‐I exerts a potential hypoglycemic effect in streptozotocin‐induced diabetic rats. The molecular mass, monosaccharide composition, structural characteristics, and preliminary hypoglycemic and hypolipidemic activity of sweet corncob in streptozotocin‐induced diabetic rats was investigated in this study. The results provide background and practical knowledge for the deep‐processed products of sweet corncob with high added value. Polysaccharide SCP‐80‐I has the certain hypoglycemic effect on streptozotocin‐induced diabetic rats.