Genética de la osteoporosis posmenopáusica: nuevos conocimientos y nuevos conceptos sobre su relación con los polimorfismos genéticos en la ruta estrogénica

• Autores: N. Mendoza, F. Morón, A.A. Santalla Hernández
• Localización: Revista Española de Enfermedades Metabólicas Oseas, ISSN-e 1132-8460, Vol. 17, Nº. 5, 2008, págs. 106-111
• Idioma: español
• Títulos paralelos:
  • The genetics of postmenopausal osteoporosis: New understanding and new concepts of its relationship with genetic polymorphisms in the oestrogen pathway
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• Resumen
  • español

    La osteoporosis posmenopáusica es una enfermedad compleja, sujeta a fuertes influencias ambientales pero con una base genética no menos importante, tanto en la manera de adquisición como de pérdida de la masa ósea. El estudio genéticonos está permitiendo identificar a pacientes con riesgo de padecer enfermedades comunes como ésta, y en su evolución como herramienta clínica hemos pasado de la búsqueda de genes candidatos al análisis unilocus de sus polimorfismos genéticos y sus relaciones con determinados factores ambientales. El siguiente paso será analizar las posibles interacciones génicas y la relación entre los hallazgos genéticos y la respuesta a los tratamientos más comunes. Postmenopausal osteoporosis is a complex disease, which is subject to strong environmental influences but with a no less important genetic basis, both in the manner of acquisition and loss of bone mass. Genetic studies are enabling us to identify patients at risk of suffering from common diseases like this, and in its evolution as a clinical tool we have advanced from the search for candidate genes to unilocus analysis of their genetic polymorphisms and their relationships with certain environmental factors. The next step will be to analyse possible gene interactions and the relationship between genetic findings and the response to the most common treatments.

  • English

    Postmenopausal osteoporosis is a complex disease, which is subject to strong environmental influences but with a no less important genetic basis, both in the manner of acquisition and loss of bone mass. Genetic studies are enabling us to identify patients at risk of suffering from common diseases like this, and in its evolution as a clinical tool we have advanced from the search for candidate genes to unilocus analysis of their genetic polymorphisms and their relationships with certain environmental factors. The next step will be to analyse possible gene interactions and the relationship between genetic findings and the response to the most common treatments.