To bind or not to bind: unravelling GPCR polypharmacology

• Autores: Patrick M. Sexton, Arthur Christopoulos
• Localización: Cell, ISSN 0092-8674, Vol. 172, Nº. 4, 2018, págs. 636-637
• Idioma: inglés
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• Resumen

  • Interaction of a single drug with multiple targets through “polypharmacology” is increasingly recognized as necessary for treatment of complex diseases, such as schizophrenia. G protein-coupled receptors (GPCRs) are major medicinal targets, and understanding the structural basis of both GPCR drug selectivity and promiscuity could provide novel avenues for drug development.