New, locally endemic species of Gymnanthes are described from Bolivia (G. microphylla) and Colombia (G. hirsuta). Both species are characterized, among other features, by a specific indumentum different from each other and from other, related species. In addition, two species from Venezuela are discussed: G. apiculata is proposed as a synonym of Actinostemon caribaeus, and the name G. hypoleuca is lectotypified.
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