The relationship between esophageal cancer, chagasic megaesophagus and HPV: myths, tales or reality?

• Fernanda Franco Munari ^[1] ; Adriana Cruvinel Carlon ^[1] ; Vânia Sammartino Mariano ^[1] ; Kari Syrjanen ^[2] ; Rui Manuel Reis ^[1] ; Adhemar Longatto-Filho ^[1]
  1. [1] Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil
  2. [2] Department of Clinical Research - Biohit Oyj, Finland
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 33, Nº. 11, 2018, págs. 1135-1149
• Idioma: inglés
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• Resumen

  • A supposed role for persistent high-risk human papillomavirus (HPV) infection in esophageal squamous cell carcinoma (ESCC) etiology has been suggested by a number of studies. Concomitantly, megaesophagus induced by the Trypanosoma cruzi cellcycle activity also shows a potential association with ESCC. This review discusses esophageal cancer and the potential association between chagasic megaesophagus and HPV as risk factors for ESCC development.