The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes.

• Autores: Christian Schnell, Ali Shahmoradi, Sven P Wichert, Steffen Mayerl, Yohannes Hagos, Heike Heuer, Moritz J Rossner, Swen Hülsmann
• Localización: Brain Structure and Function, ISSN 1863-2653, ISSN-e 1863-2661, Vol. 220, Nº. 1, 2015, págs. 193-203
• Idioma: inglés
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• Resumen

  • Sulforhodamine 101 (SR101) is widely used for astrocyte identification, though the labeling mechanism remains unknown and the efficacy of labeling in different brain regions is heterogeneous. By combining region-specific isolation of astrocytes followed by transcriptome analysis, two-photon excitation microscopy, and mouse genetics, we identified the thyroid hormone transporter OATP1C1 as the SR101-uptake transporter in hippocampus and cortex.;