Resumen de Cortico-subthalamic connection predicts individual differences in value-driven choice bias.

Jan Mulder, Wouter Boekel, Roger Ratcliff, Birte U Forstmann

• It has been suggested that a connection between the STN and value-sensitive areas of the prefrontal cortex might mediate value-based actions in perceptual decision making. In this study, we first seek to quantify a structural connection between the STN and a cortical region that was associated with mechanisms underlying bias in choice behavior (vmPFC). Next, we tested whether individual differences in the probabilistic tract-strength of this connection were predictive for individual differences in the magnitude of bias in a perceptual decision-making task. Probabilistic tractography was used to measure the tract-strength between the STN and the vmPFC. Bias was quantified using an accumulation-to-bound model where a shift in the starting point of the accumulation of sensory evidence causes faster and more choices for an alternative that is more likely or more valuable. Results show that vmPFC is structurally connected with the STN and that the strength of this connection is predictive for choice bias towards an alternative that is more valuable, but not for choice bias towards an alternative that is more likely. These findings confirm the involvement of the cortico-subthalamic circuit in mechanisms underlying value-based actions in perceptual decision making.;