Gastric Carcinoids

• Autores: Simona Grozinsky-Glasberg, Krystallenia I. Alexandraki, Anna Angelousi, Eleftherios Chatzellis, Stavros Sougioultzis, Gregory Kaltsas
• Localización: Endocrinology and metabolism clinics of North America, ISSN 0889-8529, Vol. 47, Nº. 3, 2018 (Ejemplar dedicado a: Innovations in the Management of Neuroendocrine Tumors), págs. 645-660
• Idioma: inglés
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• Resumen

  • Gastric carcinoids, formally named gastric neuroendocrine neoplasms (NENs), are derived from enterochromaffin-like cells of the stomach and are increasingly diagnosed. A majority are designated as type I (related to autoimmune gastritis) and type II (related to gastrinoma) neoplasms that develop secondary to gastrin hypersecretion. Types I and II gastric carcinoids are mostly small-sized (1–2 cm), multiple, low-malignancy potential lesions mainly confined to the gastric mucosa/submucosa. These lesions have an indolent course and low metastatic potential. In contrast, type III gastric carcinoids are single, larger-sized (>2 cm), non–gastrin-related lesions that infiltrate the muscular layers associated with local and distant metastases.