Resumen de Molecular Genetic Studies of Pancreatic Neuroendocrine Tumors: New Therapeutic Approaches

Kate E. Lines, Rajesh V. Thakke, Mark Stevenson

• Pancreatic neuroendocrine tumors (PNETs), which account for 1% to 2% of all pancreatic neoplasms, are pathologically heterogeneous and consist of epithelial cells with phenotypic and ultrastructural neuroendocrine differentiation.

  PNETs may be classified according to their proliferation, which is assessed by the Ki-67 index or mitotic count. Well-differentiated PNETs grade (G)-1 have a Ki-67 index of less than