The purpose of this paper is to analyse the portrayal of triple therapy (a combination of three antiviral drugs proposed at the Vancouver International AIDS Conference in 1996) in three literary texts belonging to the Latin American HIV-positive corpus. Our aim is to track the changes in relation to previous AIDS narratives in three areas: feelings of guilt, everyday life and the search for love/eroticism. The selected corpus consists on the autobiography Un año sin amor. Diario del sida (1998) by the Argentine author Pablo Pérez, the novel La promesante (2001) by the Nicaraguan writer Rosario Aguilar and the chronicle Vivir con virus. Relatos de la vida cotidiana (2004) by the Argentine journalist Marta Dillon.
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