Resumen de Ciprofloxacin-phenytoin interaction: Preventing seizures when serum assay is not possible
Cássio Alexandre Oliveira Rodriguez, Eduardo Queiroz Da Cunha, Valdjane Saldanha, Rand Randall Martins
Drug interaction between ciprofloxacin and phenytoin, presents an unknown mechanism, besides clinical impacts and management that are not very well described. This is a case of a female patient, 82 years old, who was taking phenytoin due to seizure episode after an occipital hemorrhagic stroke and presented a new seizure episode after initiating ciprofloxacin. Monitoring of serum phenytoin levels with subsequent dose adjustments is recommended, however, it is important to highlight the difficulties involved in this process. We report the occurrence of seizure related to the interaction between phenytoin and ciproflowacin and recommend increasing the dose by 50% according to required
