Maternal IgG and IgA antibodies dampen mucosal T helper cell responses in early life

• Autores: Meghan A. Koch, Gabrielle L. Reiner, Kyler A. Lugo
• Localización: Cell, ISSN 0092-8674, Vol. 165, Nº. 4, 2016, págs. 827-841
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • To maintain a symbiotic relationship between the host and its resident intestinal microbiota, appropriate mucosal T cell responses to commensal antigens must be established. Mice acquire both IgG and IgA maternally; the former has primarily been implicated in passive immunity to pathogens while the latter mediates host-commensal mutualism. Here, we report the surprising observation that mice generate T cell-independent and largely Toll-like receptor (TLR)-dependent IgG2b and IgG3 antibody responses against their gut microbiota. We demonstrate that maternal acquisition of these antibodies dampens mucosal T follicular helper responses and subsequent germinal center B cell responses following birth. This work reveals a feedback loop whereby T cell-independent, TLR-dependent antibodies limit mucosal adaptive immune responses to newly acquired commensal antigens and uncovers a broader function for maternal IgG.