Thoughts on obesity and brain glucose

• Autores: Michael T. Heneka, Pierluigi Nicotera
• Localización: Cell, ISSN 0092-8674, Vol. 165, Nº. 4, 2016, págs. 773-775
• Idioma: inglés
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• Resumen

  • Homeostatic control of brain metabolism is essential for neuronal activity. Jais et al., (2016) report that reduced brain glucose uptake elicited by a high-fat diet self-corrects by the recruitment of peripheral, VEGF-producing macrophages to the blood-brain barrier. Their findings further suggest that restoring brain glucose availability might help protect from cognitive impairment in Alzheimer’s disease.