Tension-time integrals and genetic cardiomyopathy: the force is with you

• Autores: Gerald W. Dorn II
• Localización: Cell, ISSN 0092-8674, Vol. 165, Nº. 5, 2016, págs. 1049-1050
• Idioma: inglés
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• Resumen

  • Hundreds of different mutations in genes encoding a few dozen sarcomeric proteins cause two reciprocal human disease phenotypes, hypertrophic or dilated cardiomyopathy. How molecular dysfunction evokes different patterns of cardiac remodeling is unclear. Davis et al. describe a biophysical metric of cardiomyocyte function, the force-time integral, which predicts disease phenotype.