Protective effects of the pericellular matrix of chondrocyte on articular cartilage against the development of osteoarthritis

• Chenlu Liu ^[3] ; Beiyu Wang ^[1] ; Li Xiao ^[3] ; Yefu Li ^[2] ; Lin Xu ^[2] ; Zhihe Zhao ^[1] ; Lin Zhang ^[1]
  1. [1] Sichuan University

     Sichuan University

     China

     
  2. [2] Harvard Medical School

     Harvard Medical School

     City of Boston, Estados Unidos

     
  3. [3] Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA

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• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 33, Nº. 8, 2018, págs. 757-764
• Idioma: inglés
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• Resumen

  • Understanding the pathogenesis of osteoarthritis (OA) provides invaluable information in the search of therapeutic targets for the development of disease-modifying OA drugs. Emerging results from investigations demonstrate that the pericellular matrix of chondrocytes plays important roles in protecting articular cartilages from being degraded. Thus, maintaining the structural integrity of the pericellular matrix may be an effective approach to prevent the development of osteoarthritic joints. In this review article, we discuss the consequences of lacking one or more components of the pericellular matrix, and biological effects of the destruction of the pericellular matrix in the development of OA. We believe that more attention should be directed towards the pericellular matrix for the identification of novel biomarkers and therapeutic targets for the prevention and treatment of OA.