Changing perspectives in atopic dermatitis
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E. Serra-Baldrich [6] ; J.O. de Frutos [7] ; I. Jáuregui [1] ; J.C. Armario-Hita [2] ; J.F. Silvestre [3] ; L. Herraez [7] ; A. Martín-Santiago [8] ; A. Valero [4] ; J. Sastre [5]
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[1] Hospital Universitario de Basurto
Hospital Universitario de Basurto
Bilbao, España
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[2] Hospital Universitario de Puerto Real
Hospital Universitario de Puerto Real
Puerto Real, España
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[3] Hospital General Universitario de Alicante
Hospital General Universitario de Alicante
Alicante, España
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[4] Hospital Clinic Barcelona
Hospital Clinic Barcelona
Barcelona, España
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[5] Fundación Jiménez Díaz
Fundación Jiménez Díaz
Madrid, España
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[6] Hospital Sant Pau, España
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[7] Hospital 12 Octubre, España
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[8] Hospital Son Espases, España
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- Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 46, Nº. 4, 2018, págs. 397-412
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Atopic dermatitis (AD) is a multifaceted disease that involves a complex interplay between the skin and the immune system. The course of the disease depends strongly on the genetic background of the patient and on yet poorly-defined environmental factors. Changes in lifestyle could be behind the dramatic rise in the prevalence of AD across continents; including hygienic conditions, food, social habits, skin microbiome or exposure to a number of allergens. Although AD typically develops in childhood and disappears after a few years, in a relatively large number of patients it continues into adulthood. Adult AD can also appear de novo but it is often underdiagnosed and its treatment can be challenging. New, highly effective drugs are being developed to manage moderate and severe forms of the disease in adults. In this review, we highlight the most recent developments in diagnostic tools, current insights into the mechanistic basis of this disease, and therapeutic innovations.
