Evaluation of antioxidant potential of methanolic leaf extract of Anacardium Occidentale (Linn) on the testes of streptozotocin-induced diabetic wistar rats

• Autores: Victor Ukwenya, Olumide Ashaolu, David Adeyemi, Efere Obuotor, Abiola Tijani, Abayomi Biliaminu, Ezekiel A. Caxton-Martins
• Localización: European Journal of anatomy, ISSN-e 1136-4890, Vol. 17, Nº. 2, 2013, págs. 72-81
• Idioma: inglés
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• Resumen

  • Anacardium occidentale is a plant with reported anti-diabetic and antioxidant properties. The objective of this work was to determine the effects of Anacardium occidentale leaf extract (AOLE) on the activities of glucose-6-phosphate dehydrogenase (G-6-PDH), thiobarbituric acid reactive substances (TBARS) and anti-oxidant enzymes (Glutathione peroxidase, GPx and superoxide dismutase, SOD) in the testicular homogenate of streptozotocin-induced diabetic rats. Forty (40) wistar rats (Rattus norvegicus) were randomly divided into four experimental groups. Diabetes was induced by a single intraperitoneal injection of Streptozotocin (70 mg/kg b.w.). Five days after the confirmation of hyperglycemia, Groups A and B were treated with 300 mg/kg b.w of the extract and 1 I.U/kg b.w. insulin respectively. Groups C and D served as hyperglycemic and normal controls respectively. Animals were sacrificed 16 days after treatment. Our study showed that AOLE ameliorated the level of TBARS and improved the activities of G-6-PDH, SOD and GPx in the testes of extract-treated rats.